Inhibitory Effects of Milk Gangliosides on the Adhesion of Escherichia coli to Human Intestinal Carcinoma Cells
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概要
- 論文の詳細を見る
The effects of milk gangliosides and their derivatives on the adhesion of enterotoxigenic and enteropathogenic Escherichia coli to Caco-2 cells, a human intestinal carcinoma cell line, were investigated. Human milk gangliosides inhibited the adhesion of enterotoxigenic E. coli to Caco-2 cells in the same proportion, regardless of the lactation stage, but bovine milk gangliosides were less effective. The most effective inhibitor was monosialoganglioside 1 (G_<M1>) ; the adhesion rate of enterotoxigenic E. coli in the presence of G_<M1> was less than 20% of the positive control. The adhesion of E. coli was also depressed to 31.4% by monosialoganglioside 3(G_<M3>). However, the inhibitory effect of disialoganglioside 3(G_<D3>) was less than that of G_<M3>. G_<D3> lactone, ceramide lactoside, and N-acetylneuraminic acid did not inhibit E. coli adhesion to Caco-2 cells. G_<M3> also inhibited the adhesion of enteropathogenic E. coli to Caco-2 cells. Thus, these results suggest that G_<M3> possibly behaves as a physiological component in the intestinal tract of infants to protect them against enteric infections.
- 社団法人日本農芸化学会の論文
- 1995-01-23
著者
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KAWAKAMI Hiroshi
Technology and Research Institute, Snow Brand Milk Products Co., Ltd.
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Idota Tadashi
Technical Research Lnstitute Snow Brand Milk Products Co. Ltd.
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Idota Tadashi
Technical Research Institute Snow Brand Milk Products Co. Ltd.
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Kawakami Hiroshi
Technical Research Institute Snow Brand Milk Products Co. Ltd.
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