Inhibition of Cholera Toxin by Human Milk Fractions and Sialyllactose
スポンサーリンク
概要
- 論文の詳細を見る
The effects of human milk fractions on clolera toxin B subunit binding to monosialoganglioside 1 (G_<M1>) were investigated. Human milk, human defatted milk, whey, and a low-molecular-weight fraction of human milk inhibited the binding, but casein did not inhibit it. The inhibitory activity of whey from bovine-milk-based infant formula was less than that of whey from human milk. Differences in composition between human and bovine whey seemed to influence the extent of the inhibitory activity. Sialylated oligosaccharides were considered to be the possible components that inhibited cholera toxin. The effects of sialyllactose, a predominant sialylated component of human milk, on cholera toxin-induced diarrhea were investigated by the rabbit intestinal loop method. Sialyllactose inhibited the cholera toxin inducing fluid accumulation, although neither sialic acid nor lactose had an effect on it. The results suggest that sialyllactose is responsible for the inhibitory activity of milk on cholera toxin.
- 社団法人日本農芸化学会の論文
- 1995-03-23
著者
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KAWAKAMI Hiroshi
Technology and Research Institute, Snow Brand Milk Products Co., Ltd.
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Idota Tadashi
Technical Research Lnstitute Snow Brand Milk Products Co. Ltd.
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Idota Tadashi
Technical Research Institute Snow Brand Milk Products Co. Ltd.
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Makihiro Sugawara
Technical Research Lnstitute Snow Brand Milk Products Co. Ltd.
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Murakami Yuji
Technical Research Lnstitute Snow Brand Milk Products Co. Ltd.
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Yuji Murakami
Technical Research lnstitute, Snow Brand Milk Products Co., Ltd.
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Kawakami Hiroshi
Technical Research Lnstitute Snow Brand Milk Products Co. Ltd.
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Kawakami Hiroshi
Technical Research Institute Snow Brand Milk Products Co. Ltd.
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