食餌性アレルギーの免疫学的研究 : 第2編.^<131>I結合卵白アルブミンによって検出されるIgG, IgA抗体及び未同定の抗体について

概要

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1) Immunoelectrophoresis and immunodiffusion were carried out with serum from a patient sensitive to egg. IgG- and IgA antibodies were detected with use of I^<131> egg albumin and anti human serum. Unidentified antibody to egg albumin was detected by direct reaction between the patient serum and I^<131> egg albumin. This unidentified antibody did not form any precipitin band against anti IgG, IgA, IgM, IgD, Fab and anti immunoglobulin serum. It is not clear that this antibody is one against a minor component of the egg albumin preparation, or this is another immunoglobulin than IgG, IgA, IgM and IgD. 2) PK activity was found also in IgG fraction which was eluated in DEAE cellulose column chromatography with pH. 8.0, 0.001 M phosphate buffer. It seems, therefore, that reagin to egg is eluated ealier than reagin to ragweed pollen which was reported by other authors. 3) Two IgA precipitin bands were shown in allergic and non-allergic persons by anti immunoglobulin serum which was prepared by immunization with anti human Fab- human immunoglobulin complex to rabbits. This immunization method might detect minor differences of H chains of IgA molecules.
日本アレルギー学会の論文
1968-09-30