Chlorophyllinの補体作用阻止効果および抗アナフィラキシー作用に就いて

概要

論文の詳細を見る
Lysis of host cell caused by the antigen-antibody reaction is associated with various phenomena in hypersensitivity and numerous evidences incibated that the immune cytolysis would be an important etiological process in allergy as defined by von Pirquet. Immune cytolysis of sheep erythrocytes with its rabbit antibody and guinea pig complement has been considered as a model experiment. Employing this mean, the author examined the inhibitory action of more than one hundred samples on the immune hemolysis as a screening test for anti-allergic agents. Of these, chlorophyllin and a series of its derivatives were found to be most potent in inhibiting the immune hemolysis. Combined injection of antibody with chlorophyllin also completely ingibits the PCA reaction with BSA system after injection of the antigen. Schultz-Dale reaction with the horse serum system is also inhibited.
日本アレルギー学会の論文
1965-09-30