Tetracosactide(β^<1-24>ACTH)のアレルギー惹起性 : 第1報.ウサギに対するTetracosactideの抗原性について

概要

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1) The immunogenicity of NH-ACTH extracted from the pituitary glands of pigs and synthetic ACTH (tetracosactide) consisted of 24 amino acids was investigated in rabbits. 2) Two of five sera of the rabbits immunized with NH-ACTH gave positive PCA reaction to NH-ACTH, and reacted with I^<131>-labelled NH-ACTH in the radioimmunoelectrophoresis. One rabbit died in a state of anaphylactic shock. 3) No antibody against tetracosactide was detected by the PCA and radioimmunoelectrophoresis in the sera of the rabbits immunized with tetracosactide. 4) The tetracosctide was non-reactive with the antiNH-ACTH antibody in the PCA and radioimmunoelectrophoresis. 5) It seems, therefore, that tetracosactide (β^<1-24> ACTH) is not immunogenic in rabbits.
日本アレルギー学会の論文
1969-01-30