学童について検査したツベルクリン皮内反応と血中抗体との関係

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Scattered data in the previous reports concerning the correlation among humoral antibodies, tuberculin skin reaction and the BCG administration on primary school children are brought together and discussed. From the readjusted results were drawn the followings. 1) The level of tuberculous humoral antibodies, in general, is elevated after the BCG administration, and maintained its level for more than three months. After one year, almost all of the cases are proved to be negative of humoral antibodies inspite of positive tuberculin skin reaction. 2) Difference in pattern of tuberculous infection between urban and rural lives which can not be defined by only the tuberculin skin test, can be seen by referring to humoral antibodies. 3) The levels of humoral antibodies in cases suffered from the BCG ulceration as well as in the naturally infected cases, in general, are high and maintained for long duration. Thus, the case with high level of humoral antibodies, even when they are proved to be negative reactors in the tuberculin skin test, might be excluded from the indication of the BCG administration. 4) It is considered that repeated tuberculin skin test as well as the BCG administration might cause the so-called early or late turn out of positive skin reaction. 5) At the stage, shortly after the BCG administration or natural infection, positivity of the tuberculin skin reaction tested with such high diluted tuberculin solution as 1:10,000 is proved to be specifically high. Further, the BCG ulceration is observed very often in cases who were proved to be positive in the tuberculin skin test with such high diluted tuberculin solution. Thus the authors are of the opinion that both of the detection of humoral antibodies and the tuberculin skin test with high diluted tuberculin solution may be effective for the early diagnosis and prevention of the BCG ulceration.
日本アレルギー学会の論文
1960-12-01

学童について検査したツベルクリン皮内反応と血中抗体との関係

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