「胃粘膜に於ける抗原抗体反応」Passive Mucosal Anaphylaxis 並に可溶性抗原抗体結合物の胃粘膜への応用

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From the immunological standpoints, we have examined Ag-Ab reaction in the gastric mucosa of experimental animals, using BSA as Ag, anti-BSA rabbit serum as Ab, and Pontamine Sky Blue as indicator. 1) Applying the technique of "Passive Cutaneous Anaphylaxis" (PCA), we obtained the interesting results which might be called "Passive Mucosal Anaphylaxis" (PMA), that is PCA in the gastric mucosa of guinea pig and dog. 2) After the soluble Ag-Ab complex was injected in the gastric mucosa, there observed the formation of erosion or ulcer within two hours. Histologically, chief cells of stomach were almost destroyed in the reaction area, whereas some of parietal cells were still remained. Marked cell-infiltrations were also observed in the destroyed gastric mucosa and around the small vessels in the submucosa. 3) After fixation of Ab in the gastric mucosa by injection directly to the mucosa, Ag was given orally. Two to six hours later, obvious leakage of dye was observed in the injected area of Ab. This mean the increase of vascular permeability by Ag-Ab reaction. In Ag-Ab reaction, complement components in serum participate with such phenomena as cell damage, increase of vascular permeability and cell infiltration, which might be explained by the mechanism of immune cytolysis, vasolysis and cell infiltration. Although many investigators have reported on Ag-Ab reaction in gastric mucosa, these reactions are so complicated with many modifiers, that it is difficult to recognize weather these reactions are really caused by Ag-Ab reactions themselves. To avoid the complexity, we have performed model experiments under purified Ag-Ab system. Thereafter, these experiments throw some lights on the immunological nature in the course of digestive diseases.
1966-06-30

「胃粘膜に於ける抗原抗体反応」Passive Mucosal Anaphylaxis 並に可溶性抗原抗体結合物の胃粘膜への応用

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