漢方方剤桂枝茯苓丸の剤形による成分の違い及びエキス化における成分変化

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Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan, 桂枝茯苓丸) is used with decoction and pill (preparation of crude drugs powder) . Crude drugs powder, decoction and this dry extract of Keishi-bukuryo-gan were compared by ten kinds of indicator components. In decoction paeoniflorin was detected about 2.5 times in the crude drugs powder per each dose of one day. On the other hand, triolein and pachymic acid were hardly found in decoction, while they were detected each 166 and 1.5 mg/day in the crude drugs powder. Therefore, the pill was found to be an indispensable dosage form for intake of some components. As for the commercial non-prescription pills, the quality was not constant. Then, it was necessary to supply the prescription pill to which the standard was properly set. Refinement of oil element cinnamaldehyde to which 30-40 % of the raw material inside has shifted in decoction and paeonol are hardly detected in the spray drying method. Amygdalin and pentagalloylglucose decreased greatly to 1/2 and 1/3 respectively, though a big change is not seen in all elements in the freeze-drying method when decoction is processed to a dry extract, too. Moreover, other elements, paeoniflorin, galloylpaeoniflorin, cinnamic acid, and bennzoic acid also showed the decrease tendency. As for the commercial extract products, the element patterns were approximated to that of the spray dried extract, and the problem was found from the viewpoint of equality with decoction. It seemed that the improvement of manufacturing technology was necessary for the solution.
和漢医薬学会の論文
2000-04-28

漢方方剤桂枝茯苓丸の剤形による成分の違い及びエキス化における成分変化

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