漁村と農山村住民における血漿脂肪酸組成および血小板凝集能と循環器系疾患について

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To elucidate correlation between diet and incidence of circulatory diseases such as atherosclerosis and thrombosis, a epidemiological investigations were undertaken on 308 inhabitants in the fishing island and 209 inhabitants in the farm village in Mie Prefecture. In the age-adjusted prevalences of coronary heart disease and cerebrovascular disease were 1.5 and 3.5 time higher, respectively, in the farm village than the other. Paralleled investigations on diet and fatty acid composition in plasma indicated that the fishing habitants have apparently higher levels in both n-3 and n-6 unsaturated fatty acids content as well as EPA/AA ratio. While, in the case of oleic acid content, the fishing inhabitants showed somewhat lower level than the others. Despite these fatty acid composition, in the case of the platelet aggregation activity, that of the fishing inhabitants were apparently greater than the others. Moreover, comparative investigations of the arteriosclerosis index also indicated ap-parent higher values in the fishing inhabitants than the others. Therefore, further investigation was made on correlation of the arteriosclerosis index and the total fatty acid content in plasma and demonstrated that inhabitants of the higher group in the arteriosclerosis index showed higher value in the total fatty acid content in plasma. These results indicated that dominant of the fishing habitants in the prevention of circulatory diseases was also observed, and assumed to be caused by enough intake of n-3 unsaturated fatty acids from fishes. However, lower activities observed in the platelet aggregation and the arteriosclerosis index might probably due to too much unsaturated fatty acid in the recommended fatty acid valance of intake diet fats.
東海学園大学の論文

漁村と農山村住民における血漿脂肪酸組成および血小板凝集能と循環器系疾患について

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