N-hydroxy amides. I. Synthesis of N-benzyloxy and N-hydroxy peptides via polymerization of N-benzyloxy DL-.ALPHA.-amino acid N-carboxy anhydrides.
スポンサーリンク
概要
- 論文の詳細を見る
Polymerization of <I>N</I>-benzyloxy DL-α-amino acid <I>N</I>-carboxy anhydrides (<I>N</I>-benzyloxy-NCAs) has been carried out in benzene for 30 d with cyclohexylamine as initiator. The N-benzyloxy-NCAs of glycine, alanine, 2-aminobutyric acid, and leucine give the corresponding polymers in good yields, while the starting material is recovered from those of valine and phenylalanine. The different behavior in the polymerization is discussed in terms of steric crowding. Catalytic hydrogenation of the <I>N</I>-benzyloxy polymers produces poly(<I>N</I>-hydroxy peptide)s. Complex formation of these polymers with iron(III) has been examined. Among the polymers, poly(<I>N</I>-hydroxyalanine) is further converted into poly(<I>N</I>-acetoxyalanine), which acts as an acyl active polymer. Treatment of poly(<I>N</I>-benzyloxyalanine) with B(CF<SUB>3</SUB>CO<SUB>2</SUB>)<SUB>3</SUB> gives 1,4-dihydroxy-3,6-dimethyl-2,5-piperazinedione.
- 公益社団法人 日本化学会の論文
著者
-
Akiyama Masayasu
Department Of Applied Chemistry Tokyo University Of Agriculture And Technology
-
Shimizu Kazuyuki
Department Of Biochem.engineering And Science Kyushu Institute Of Technology
-
Hasegawa Masayoshi
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
-
Akiyama Masayasu
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
-
Shimizu Kazuyuki
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
関連論文
- Metabolic Pathway Analysis of Recombinant Saccharomyces cerevisiae with a Galactose-Inducible Promoter Based on a Signal Flow Modeling Approach
- Phase II and pharmacokinetic study of thalidomide in Japanese patients with relapsed/refractory multiple myeloma
- Quantitative Analysis of Intracellular Metabolic Fluxes Using GC-MS and Two-Dimensional NMR Spectroscopy
- Metabolic Control Analysis for Lysine Synthesis Using Corynebacterium glutamicum and Experimental Verification
- Development of a Kinetic Model for L-Lysine Biosynthesis in Corynebacterium glutamicum and Its Application to Metabolic Control Analysis
- Metabolic Flux Analysis for Efficient Pyruvate Fermentation Using Vitamin-Auxotrophic Yeast of Torulopsis glabrata
- Metabolic Flux Analysis for Biosynthesis of Poly(β-Hydroxybutyric Acid) in Alcaligenes eutrophus from Various Carbon Sources
- Efficient Production of Vitamin B_ from Propionic Acid Bacteria under Periodic Variation of Dissolved Oxygen Concentration
- Application of Artificial Neural Network and Fuzzy Control for Fed-Batch Cultivaton of Recombinant Saccharomyces cerevisiae
- Performance Improvement of Lactic Acid Fermentation by Multistage Extractive Fermentation
- Fuzzy Neural Network for the Control of High Cell Density Cultivation or Recombinant Escherichia coli
- Effect of Controlling Lactate Concentration and Periodic Change in DO Concentration on Fermentation Characteristics of a Mixed Culture of Lactobacillus delbrueckii and Ralstonia eutropha for PHB Production
- Rapid Production of Pediococcus halophilus Salt-Tolerant Cells by a Cultivation Method Employing Gradual Increases in NaCl Concentration Using a Fermentor with a Microfiltration Module
- Posttreatment M-Protein Nadir Level Is a Significant Prognostic Factor Associated with Survival in Multiple Myeloma
- Continuous Lactic Acid Production from Raw Starch in a Fermentation System Using a Reversibly Soluble-autoprecipitating Amylase and Immobilized Cells of Lactobacillus casei(Microbiology & Fermentation Industry)
- Development of Dual On-Line Analyzer and Its Application to Fed-Batch Lactic Acid Fermentation
- Adaptive On-Line Optimizing Control for Lactic Acid Fermentation
- pH-Mediated Control Methods for Continuous Ethanol Fermentation Using Zymomonas mobilis
- Hodgkin's disease following extranodal marginal zone B-cell lymphoma in remission
- Targeting of Soybean-Derived Sterylglucoside Liposomes to Liver Tumors in Rat and Mouse Models
- Formulation of Liposomes with a Soybean-Derived Sterylglucoside Mixture and Cholesterol for Liver Targeting
- Neuro-Fuzzy Control of Bioreactor Systems with Pattern Recognition
- On-Line Control of Glucose Concentration Using An Automatic Glucose Analyzer
- Association of Liposomes Containing a Soybean-Derived Sterlyglucoside Mixture with Rat Primary Cultured Hepatocytes
- Design and Synthesis of Artificial Siderophores: Lysine-based Triscatecholote Ligands as a Model for Enterobactin
- Knowledge-Based Design and Operation of Bioprocess Systems
- Artificial Siderophores as a Model for Ferrichrome. Control of the Δ-or 〓Λ-Configuration of Iron(III) Complexes of Tripodal Hydroxamates by Linking to the C - or N-Terminus of the Same L-Alanyl-L- alanyl-β-(N-hydroxy) alanine Unit
- Proteome Analysis of a Temperature-Inducible Recombinant Escherichia coli for Poly-β-Hydroxybutyrate Production
- An Integrated Metabolic Pathway Analysis Based on Metabolic Signal Flow Diagram and Cellular Energetics for Saccharomyces cerevisiae
- 571 Computer-mediated addition of fresh medium in continuous culture of Zymomonas mobilis by the monitoring of weight changes
- Hepatic Branched-Chain α-Keto Acid Dehydrogenase Complex in Female Rats : Activation by Exercise and Starvation
- Application of Dual-Energy K-Edge Subtraction Imaging to Assessment of Heat Treatments in Al-Cu Alloys
- Modification of Metabolic Pathways of Saccharomyces cerevisiae by the Expression of Lactate Dehydrogenase and Deletion of Pyruvate Decarboxylase Genes for the Lactic Acid Fermentation at Low pH Value
- Iron(III)Complex of a Trihydroxamate Ligand with an Ala-Ala-(HO)Gly-Ala Sequence as a Model for Ferrioxamines. Formation of Well-Defined Peptide Loop Structure
- Effect of Modifying Metabolic Network on Poly-3-Hydroxybutyrate Biosynthesis in Recombinant Escherichia coli
- Temperature-Induced Expression of phb Genes in Escherichia coli and the Effect of Temperature Patterns on the Production of Poly-3-Hydroxybutyrate
- Efficient Production of Gene Products by Repeated Fed-Batch Fermentation Using Multiple Fermentors
- Solvent extraction of plant pigments from leaf protein concentrate.
- N-Hydroxy amides. IV Synthesis and properties of a trihydroxamic acid anilide as a model for ferrioxamines.
- N-hydroxy amides. I. Synthesis of N-benzyloxy and N-hydroxy peptides via polymerization of N-benzyloxy DL-.ALPHA.-amino acid N-carboxy anhydrides.
- Comparison of control techniques for baker's yeast culture using an automatic glucose analyzer.
- N-hydroxy amides. III. Active esters of polystyrene-bound 1-hydroxy-2-pyrrolidinone and their use in peptide synthesis.
- On the expansion of the transfer function for the model reduction of stage systems.
- Singular value analysis for the Robust control system design of distillation systems.
- Control of cell and lactate concentration in a hollow-fiber bioreactor for lactic acid fermentation.