N-hydroxy amides. III. Active esters of polystyrene-bound 1-hydroxy-2-pyrrolidinone and their use in peptide synthesis.
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概要
- 論文の詳細を見る
A polymer-bond cyclic <I>N</I>-hydroxy amide has been prepared by reaction of aminomethylated copoly(styrene–2% divinylbenzene) with 1-hydroxy-5-oxo-3-pyrrolidinecarboxylic acid using dicyclohexylcarbodiimide (DCC) as a condensing agent. Several <I>N</I>-blocked α-amino acids have been loaded on this resin by use of DCC. The amino acid resin can be utilized for peptide synthesis. Repetitive usage of the resin in the form of esters and facile synthesis of a biologically active pentapeptide, Leu<SUP>5</SUP>-enkephalin, show the usefulness of the polymer-bound 1-hydroxy-2-pyrrolidinone.
- 公益社団法人 日本化学会の論文
著者
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Katoh Hiroaki
Department of Internal Medicine, Toyama Prefectural Central Hospital
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Shimizu Kazuyuki
Department Of Biochem.engineering And Science Kyushu Institute Of Technology
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Aiba Seiichi
Department Of Organic Materials Osaka National Research Institute
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Akiyama Masayasu
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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Shimizu Kazuyuki
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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Aiba Seiichi
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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Katoh Hiroaki
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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