糖尿病患者の細胞性免疫学的研究 (第三報) -糖尿病患者におけるリンパ球Subpopulation-

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There is an increasing evidence that autoimmune mechanisms may have a role in the pathogenesis in insulin-dependent diabetics. The numerical and functional study of peripheral blood lymphocytes in diabetes mellitus might indirectly contribute to the understanding of its pathogenesis.<BR>In this study, detection of peripheral blood T lymphocytes was measured by rosettes with sheep red blood cells (SRBC), and B lymphocytes were measured by immunofluorescence with specific antiserum to immunoglobulins.<BR>The mean (± SD) percentage of SRBC was 67.6 ±7.2 in 21 normal subjects, 71.5±7.0 in 15 insulin-dependent diabetics, and 68.3 ± 6.7 in 30 insulin-independent diabetics. There was no difference in the absolute T-lymphocyte number per mm<SUP>3</SUP> in these three groups. Insulin-dependent diabetics showed a normal percentage and absolute number of B lymphocytes when compared with normal subjects.
日本内分泌学会の論文