橋本病患者末梢血リンパ球のAllogeneicリンパ球およびphytomitogenに対する反応性

概要

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To investigate the role of peripheral blood lymphocytes in thyroid auto-immunity, the in vitro responsiveness to allogeneic lymphocytes (MLC) or phytomitogens was examined in the lymphocytes from patients with Hashimoto's thyroiditis. The MLC responses of 16 patients were compared with those of age- and sex-matched normal controls. All possible combinations between lymphocytes from the patients and controls were mixed in both one-way and two-way MLC. From the results of one-way MLC, the stimulatory capacity and responding capacity of lymphocytes from the patients and controls were calculated respectively as follows : Nm→ N : 4,829 ± 3,257 (M ± SD, cpm) (1) Hm → N : 4,735 ± 3,029 (2) Nm→H : 3,716 ± 2,401 (3) To the same allogeneic stimulation of Nm (mitomycin-treated stimulating lymphocytes from controls), lymphocytes from the patients (H) exhibited a lower response (P>0.05) than did those from the controls (compare (1) with (3)). Phytomitogen-response was simultaneously studied for residual cells of MLC. Lymphocytes from the patients showed a significantly decreased (P<0.01) response to phytohemagglutinin-p and concanavalin A in comparison with the response of normal lymphocytes. From these results, it was suggested that cell-mediated immunity in vivo was impaired in Hashimoto's thyroiditis
日本内分泌学会の論文