ヒト末梢血中のthyroglobulin-binding lymphocyteとthyroglobulin antibody-secreting lymphocyteに関する研究

概要

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Human peripheral blood lymphocytes were studied with the use of fluoresceinated human thyroglobulin (FITC-Tg) for the presence of cells which bind human FITC-Tg (Tg-BL) and which secrete a thyroglobulin antibody (Tg-SL) by culturing them for 5 days with pokeweed mitogen.<BR>In seven out of fifteen (47%) patients with Hashimoto's thyroiditis, an average of 0.18% of lymphocytes were able to bind FITC-Tg, while only one out of six (17%) patients with Graves' disease was able to bind them. No Tg-BLs were detected in five patients with miscellaneous autoimmune diseases and five normal subjects. Tg-BLs were identified as B lymphocytes by their inability to make rosettes with sheep red blood cells. Tg-SLs were detected in six out of eight (75%) patients with Hashimoto's thyroiditis and two out of five (40%) patients with Graves' disease.<BR>The positive rates of Tg-BL and Tg-SL were fairly well correlated with the thyroglobulin antibody titers.