インスリン依存性糖尿病患者末梢血リンパ球のAllogeneicリンパ球およびPhytomitogenに対する反応性

概要

論文の詳細を見る
The lymphocyte transformation response to the allogeneic lymphocytes (mixed lymphocyte culture, MLC) was determined in nineteen well-controlled insulin-dependent diabetics (IDD) and nineteen matched normal subjects. All possible combinations between lymphocytes from the patients and controls were mixed in both one-way and two-way MLC. From the results of one-way MLC, the stimulatory capacity (SC) and responding capacity (RC) of IDD lymphocytes were compared with those of normal lymphocytes as follows : (1) Nm→N : 10,538 ± 3,937 N; normal lymphocytes (2) Nm→D : 8,466 ± 5,387 D; IDD lymphocytes (3) Dm→N : 7,562 ± 3,088 m; mitomycin-treated stimulating lymphocytes (4) Dm→D : 7,102 ± 4,873 (→ ; stimulatory direction, results; M ± SD cpm) IDD lymphocytes showed a marked depressive function as stimulators (SC, (1) - (3)), but the RC of IDD lymphocytes was unchanged ((1) - (2)). Phytomitogen-response was studied simultaneously for the same responding lymphocytes (N, D) of MLC. IDD lymphocytes exhibited significantly decreased responses to phytohemagglutinin P, pokeweed mitogen and concanavalin A.
日本内分泌学会の論文