糖尿病患者の抗甲状腺抗体

概要

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In the course of studies on the occurrence of antithyroid antibodies in diabetes mellitus, serum antibodies to microsomes of thyroid epithelial cells, as well as circulating antibodies to thyroglobulin, were demonstrated by tanned red cell hemagglutination. These thyroglobulin and microsome-coated tanned red blood cells can be efficiently made with a commercially prepared reagent. (Fuji Zoki Co. Tokyo) The sera of 507 diabetics and 2,350 normal subjects was tested using these thyroid autoantibodies tests. In diabetics, the percentage of sera positive for antithyroglobulin antibodies was found to be 2.5% compared with 2.3% in controls. And the percentage of sera positive for antimicrosomal antibodies was found to be 6% compared with 2.5% in controls. In diabetics treated with insulin, the percentage of antithyroglobulin antibodies and antimicrosomal antibodies were found to be 5% and 16% respectively. In diabetics not treated with insulin, the percentage of thyrid antibodies were 2% and 3% respectively. The incidence of antithyroglobulin and antimicrosomal antibodies was higher in diabetics treated with insulin. The incidence of thyroid antibodies in normal subjects was found to be increased with aging, but in diabetics the incidence of thyroid antibodies was found to be decreased with aging. There was no clear relationship between the incidence of these antibodies with the duration of diabetes.
日本内分泌学会の論文