2:4 Dinitrochlorobenzene (2:4-D) 感作海〓に於ける副腎皮質の形態学的研究
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In the experimental studies of drug-sensitization, marked differences were often observed in the intensity of skin reaction to the test on the sensitized animals, all of which recieved the same treatment. As for the differences, even among homologous animals, it has been vaguely expressed so far that the differences possibly depend on the variety of individual characters. Recently many reports have been accumulated about the relationship between corticotrophin or adrenal hormones and allergic reactions. The authors too have researched the relation of adrenal cortex to the intensity of allergic skin reactions in guinea pigs sensitized with 2 : 4-dinitrochlorobenzene, and in this paper we are reporting the morphological studies on adrenal cortex of normal and sensitized guinea pigs, some of which were exposed to a stressor, taking out a large amount of lymph from the thoracic duct. <BR>The amount of lipids in adrenal cortex, decreased in general under the stresses such as sensitization and flowing out lymph through the thoracic duct, and this change was most marked at the middle layer of zone fasciculata. Among the lipids the positive substances by Ashbel-Seligman reaction decreased most prominently. As for free cholesterine, fatty acid, congestion and bleeding in adrenal cortex and the ratio of width of zona fasciculata to that of zona glomerulosa, there was seen a series of changes which were ordinarily observed under the stress. <BR>Comparing the histochemical findings of adrenal cortex of various groups with each other, lipids of the adrenal cortex in a weakly sensitized group showed lesser in amount and more minute in size than that in a strongly sensitized group. These differences between both groups became more marked when exposed to another additional stress, e.i. their lymph were drained out, and especially so in the changes of the positive substances to Ashbel-Seligman reaction. <BR>From these histological findings, and by presuming the adrenal function it can be said that weakly sensitized animals show more marked hyperfunction of adrenal cortex than strongly sensitized ones. Consequently the activity of adrenal cortex seems to have intimate relationship with the intensity of allergic reaction.
- 日本内分泌学会の論文
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