慢性甲状腺炎の臨床免疫学的研究 : 第4篇.慢性甲状腺炎の免疫病理学的研究.

概要

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The indirect immunofluorescent technique, silver stain and electron microscope were used to examine thyroid tissue obtained from 6 patients with chronic thyroiditis, 3 with hyperthyroidism and one with simple goiter. By means of and indirect immunofluorescent techique, diffuse infiltration of colloid substance into the basement membrane was observed in each specimen from chronic thyroiditis. In the demonstration of basement membranes, silver stains obscured the finer details and differences in basement membrane appearance, but otherwise confirmed the findings by electron microscope. In precipitin positive cases of chronic thyroiditis, there were diffuse abnormalities of the basement membrane. These changes consisted of smudging, reticulation, vacuolization, thinning, reduplication and discontinuities. In precipitin-negative case of chronic thyroiditis, most basement membranes were comparable to those seen in the control thyroids from patients with hyperthyroidism or simple goiter. This is suggestive evidence that the changes in the basement membrane in thyroid follicular cells may be a result from the development of chronic thyroiditis.
日本アレルギー学会の論文
1968-11-30