Expression of cellular oncogenes and their possible roles in liver regeneration.

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To investigate the involvement of cellular oncogenes in liver regeneration, we analyzed the expression of oncogenes and vitamin D receptor (VD·R) after rat partial hepatectomy (PH). The expression of c-myc, c-fos and c-Ha-ras oncogenes transiently increased after PH. c-myc mRNA was detected in the cytosol of hepatocyte 3hr after PH with in situ hybridization and the product of this oncogene was detected in the nucleus of hepatocyte 6hr after PH with immunohistochemical examination. On the other hand, no significant expression of c-erbA oncogene was detected after PH. The number of VD·R in the cytosol of hepatocyte was increased during liver regeneration and reached maximum 6hr after PH. All of these changes were observed before DNA synthesis of hepatocyte. These results indicate that oncogenes, especially c-myc, c-fos and c-Ha-ras, and VD·R play important roles in the initial process of liver regeneration.
社団法人日本肝臓学会の論文