四塩化炭素肝障害の成立,進展過程に及ぼすdiisopropyl 1,3-dithiol-2-ylidene malonate(malotilate)の影響

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Effects of diisopropyl 1, 3-dithiol-2-ylidene malonate (malotilate) on liver damage induced by CCl4 in rats were investigated by the measurement of liver and serum lipid contents and by the morphological changes of liver using light microscope (LM) and electron microscope (EM) . Carbon tetrachloride (CCl4) -induced liver damage was produced by the adminstration of CCl4 in a dose of 1.0 ml/kg, p. o.. Malotilate was administered by gavage in a dose of 250 mg/kg with CC14. Liver protein decreased by CCl4. A decrease of liver protein by CCl4 was inhibited by the combined administration of malotilate. The combined administration of malotilate inhibited increase in liver total lipid (TL) and total cholesterol induced by CCl4, but did not inhibited an increase in triglyceride. The increase in serum TL and the elevation in transaminase (GOT, GPT) by CCl4 were also inhibited by the administration of malotilate. A histological examination of the liver, using LM, showed a centrilobular fatty degeneration and necrosis by the administration of CCl4. A combined administration of malotilate with CCl4 significantly inhibited this fat-degeneration induced by CCl4. The fine structure of the liver using EM showed severe changes, including disarranged, rough endoplasmic reticulum, increased fat and swollen mitochondria. Malotilate markedly inhibited those changes induced by CCl4.
学校法人昭和大学・昭和医学会の論文