Diisopropyl 1,3-dithiol-2-ylidene malonate(malotilate)の脂質代謝に及ぼす影響

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Effect of diisopropyl 1, 3-dithiol-2-ylidene malonate (malotilate) on lipid metabolism in Sprague-Dawley rats were investigated by the mesurement of lipid contents and cholinesterase (ChE) activities in serum and liver. Malotilate was administered by gavage in a dose of 20 and 100 mg/kg daily for 4 weeks. Triglyceride (TG) and total cholesterol (TC) in liver decreased by the treatment of malotilate in the former, for 1 week and in the latter for 4 weeks. Total lipid (TL) and phospholipid (PL) in liver was not changed by the treatment of malotilate. TG and nonesterified fatty acid in serum was slightly decreased by the treatment of malotilate for 1, 2 and 4 weeks. Malotilate in a dose of 100 mg/kg, p.o. showed an increase of PL and PL in high density lipoprotein (HDL) in serum. Cholesterol in HDL in serum also increased by the treatment of malotilate for 4 weeks. Transaminase (GOT) and lactate dehydrogenase in serum were lowered by the treatment of malotilate in a dose of 100 mg/kg, p.o. for 1 week. ChE in liver, using acetylcholine and butyrylcholine as substrate, was inhibited by the treatment of malotilate for 1 week. ChE in serum, using acetyl-β-methyl-choline as substrate, was inhibited by the treatment of malotilate. Malotilate has little effect on lipid metabolism in normal animals.
学校法人昭和大学・昭和医学会の論文