L-Carnosine(N-2-M)の薬理学的研究-1-一般薬理作用

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A study was made of the general pharmacological activities of L-carnosine by using synthetic L-carnosine ; and the following were found : 1. The intraperitoneal LD50 of L-carnosine to mice was 9, 087 mg/kg. The observation of the general activities of mice and rabbits also proved L-carnosine to be a compound with very low acute toxicity. 2. L-carnosine, when administered to animals, exerted no particular effects on the CNS of the animals. The compound further proved not antagonistic to the convulsions induced with strychnine and pentetrazol. 3. L-carnosine was administered in conjunction with barbiturate, to examine its effect on the sleep induced with the latter, and it was revealed that the intraperitoneal doses of not lower than 150 mg/kg significantly prolonged the sleeping time. 4. L-carnosine failed to vary the body temperature in normothermic and hyperthermic animals. The compound further proved inert on blood coagulation, biliary secretion, pen-pheral blood vessels and transport movements of the small intestine. 5. The intravenous doses of not less than 50 mg/kg of L-carnosine caused transient hypotention in rats. 6. L-carnosine, in 0.1 to 10.0 % concentrations, exerted a surface anesthetizing effect on the rabbit cornea. 7. The intraperitoneal doses of not less than 100 mg/kg of L-carnosine were inhibitory to urination in mice.
学校法人昭和大学・昭和医学会の論文