Homotaurine-cholineの薬理学的研究--降圧作用ならびに実験的高脂血症に及ぼす影響について

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概要

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• Studies were performed to investigate the blood pressure-lowering effect of homotaurine-choline (HT-ch) and its influence on experimentally induced hyperlipidemia. HT-ch is a molecular compound of 3-aminopropanesulfonic acid (homotaurine) and choline chloride. The results were as follows:<BR>1) HT-ch produced a hypotensive effect in rats, the degree of action being approximately intermediate between homotaurine and choline.<BR>2) The data obtained indicate a possible involvement of the central nervous system in the hypotensive action of HT-ch, as is the case of homotaurine. Besides, it was also suggested that this compound of higher order being a derivative of choline might affect on effectors of cholinergic postganglionic fibers.<BR>3) Young rats with low body weights which had been maintained on a high fat diet containing 2 per cent of cholesterol and 1 per cent of cholic, acid for 3 days developed a marked hypercholesterolemia. Elevation of other serum lipids was also prominent in these animals.<BR>4) Administration of taurine or 1-amino-2-hydroxypropanesulf onic acid brought about lowering of serum lipid levels in rats with hyperlipidemia receiving high doses of these compounds. In contrast, a significant decrease in serum lipid concentration occurred following administration of homotaurine even in low doses, and the antihyperlipidemic effect was moreover marked in rats receiving HT-ch.<BR>5) Normal rats given homotaurine exhibited a significant fall of serum lipid level whereas administration of HT-ch failed to produce any significant change in this respect.

• 学校法人 昭和大学・昭和医学会の論文

著者

• 森本 祐二郎

  昭和大学医学部第一薬理学教室

関連論文

• L-Carnosine(N-2-M)の薬理学的研究-1-一般薬理作用
• L-Carnosine(N-2-M)の薬理学的研究-2-抗炎症および創傷治癒過程に及ぼす効果について
• Homotaurine-cholineの薬理学的研究--降圧作用ならびに実験的高脂血症に及ぼす影響について

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