Modified Neuroleptoanesthesia(NLA変法)のヒトならびにウサギの肝に及ぼす影響

概要

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Liver function was examined in gastric ulcer patients under anesthesia who underwent gastric resection (Billroth's method) and who showed good general conditions by modified neuroleptoanesthesia (NLA) using Droperidol and Pentazocine.<BR>Futher, liver function and liver tissue were examined in rabbits administered Droperidol and Pentazocine intravenously, and results obtained were compared with those in man.<BR>Biochemically, there was noted a decline in serum total protein of man following anesthesia. Besides, no marked change in liver function was observed in both man and rabbit.<BR>Microscopically, changes were noted up to 6 hours after anesthesia. On 24 hours, there was a tendency to recovery microscopically, but changes were still observable electron microscopically.<BR>The effect of Droperidol and Pentazocine on the liver disappears with the lapse of time ; however, it is possible that these drugs will cause a transient change in liver cells.
学校法人昭和大学・昭和医学会の論文