Diisopropyl 1,3-dithiol-2-ylidene malonate(NKK-105)の薬理学的研究-7-脳波及び脊髄反射活動電位への作用

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We observed the effects of Diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105) on EEG when used to inhibit the effect of alcohol in acute and chronic cats, and humans; and investigated the effects of NKK-105 on spinal reflex in cats. A summary of results was as follows: (1) NKK-105: 500 mg/kg (p. o.), which was physically maximal dose, alone had no influence on EEG's. (2) NKK-105 100 mg/kg (p. o.) or 5-10 mg/kg (i. v.) clearly suppressed effects of 1000-3000 mg/kg (p. o.) . (3) NKK-105: 100 or 300 mg/kg (p. o.) inhibited about 80% of the effects of 1000-1500 mg/kg (p. o.) of ethanol on 24 trials in chronic experiments. (4) 7 or 14 days continuous administration of 20 mg/kg (p. o.) of NKK-105 in six adult male healthy volunteer exhilited marked suppression to 500 mg/kg (p. o.) alcohol effects. (7) It is thus suggested that NKK-105 inhibits the effects of alcohol, possibly by acting on liver functions, and to a lesser extent in the CNS. (8) NKK-105 did not affect mono- (MSR) and polysynaptic reflexes (PSR) in doses less than 100mg/kg (i, v.), but higher doses (150 or 200 mg/kg, i. v.) markedly influenced whole body functions, inhibiting both MSR and PSR.
学校法人昭和大学・昭和医学会の論文