急性ネコ脊髄反射活動電位に及ぼすセロトニン前駆物質の影響について

概要

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The effect of L-5Hydroxytryptophan (L-5HTP), DL-5Hydroxytryptophan (DL-5HTP) and Benserazide-HCl (Ro4-4602) were investigated on the spinal ventral root reflexes by the intact and spinal cat preparations. These observation indicate that: 1) L and DL-5HTP were increased MSR but were decreased PSR. The effect of L-5HTP was faster than DL-5HTP on the spinal cord facilitation. 2) L-5HTP 75 mg/kg i, v. was not change at the case of the intact cat on neuronal activity. 3) L-5HTP 75 mg/kg by arteria carotis externa injection facilitated a shorter latency and the continuance prolonged. 4) Benserazide-HCl (Ro4-4602) 50 mg/kg i. v. inhibited MSR and PSR but 25 mg/kg i. v, not inhibited MSR and PSR. 5) Benserazide-HCl 25 mg/kg i. v. followed by L-5HTP 75 mg/kg i. v. was not change on the spinal neuronal activity. 6) L-5HTP 75 mg/kg i. v. at the same time Benserazide 25 mg/kg i. v, inhibited MSR but not inhibited PSR. 7) L-5HTP 75 mg/kg i. v, followed by Benserazide-HCl 25 mg/kg i, v. stopped the rising of MSR but not changed PSR. (3) -7) C<SUB>1</SUB>-C<SUB>2</SUB> cut, not used dTc) .
学校法人昭和大学・昭和医学会の論文