<研究論文>肥満(症)に対する運動療法 : 視床下部性肥満ラットにおける長期持久的(walking)運動は内因性中性脂肪の分泌速度および脂肪組織の脂肪分解に奏効する

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In this study we attempted to demonstrate the effects of long-term endurance exercise (walking) on endogenous triglyceride secretion rate (E-TGSR) and lipolytic activity of adipose tissue in experimental obesities induced by ventromedial hypothalamic (VMH) lesions. The rats were then divided into VMH-lesioned and sham operated sedentary group (VMH-W, 10m/min, 60min, 5days/week) and a sedentary group (VMH-S) for 12 weeks. Results indicated that the body weight in VMH-W was significantly lower (p<0.01) than that in VMH-S. The concentration of serum triglyceride (TG) in VMH-S was markedly higher (p<0.05) than that in Sham-S. The serum TG in VMH-W was significantly lower (p<0.01) than that in VMH-S. Changes in the serum cholesterol (CHL) was also similar to those of serum TG.E-TGSR in VMH-W was markedly lower (p<0.01) than that in VMH-S. Norepinephrine induced lipolysis of adipose tissue in vitro was significantly higher (p<0.05) in VMH-W than that VMH-S. It is thus suggests that walking exercise might be effective to inhibiting secretion rate of endogenous triglyceride gain and accelerating lipolysis of adipose tissue, and it might also be used effectively for exercise treatment of obesity.
東海大学の論文