実験的動脈硬化症ラットのリポ蛋白代謝に及ぼす持久的運動の影響

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The effect of endurance training was investigated on the levels of serum cholesterol and lipoprotein, distribution of lipids in the liver and arterial wall by morphological observation and systolic blood pressure of experimentally hypercholesteremic or atherosclerotic rats. Male Wistar strain rats (7-wk.-old) were divided into 3 groups. G-A was fed on a laboratory chow for 14 wk.. G-B was fed on the high fat diet for 14 wk. under the administration of vitamin D_2 for 4 days. G-C was fed on the high fat diet for 14 wk. under the administration of vitamin D_2 for 4 days and treadmill exercised 3 days a wk. for 11 wk. on and after the 3rd wk. of feeding. Upon the morphological observation of the arterial wall and liver of G-B and C, in the arterial wall the prolification and the fragmentation of elastic lamina and the accumulation of calcium, in liver the accumulation of lipids were detected and then there was no difference between G-B and G-C. The liver wt. per body wt. of G-B and G-C greatly increased. Exercise tended to restrain a increase of the liver wt. per body wt.. Serum T-cho. concentration remarkably increased in G-B and G-C. But when compared with G-B, serum T-cho. concentration of G-C tened to decrease gradually during the 11 wk. training period. Serum HDL-cho. concentration slightly increased at the 2nd wk. of feeding, and greatly increased after the 8th wk. of feeding and so there was no significant difference between G-B and G-C. Inversely, Serum Triglyceride concentration, after the 8th wk. of feeding, were significantly lower in G-B and G-C, as compared with G-A. Furthermore, Serum Triglyceride in G-C was slightly lower than G-B. On the other hand, HDL-cho./T-cho. ratio remarkably decreased at the 2nd wk. of feeding in G-B and G-C, and followed by gradual increase. Wheras G-C had greater increase of HDL-cho./T-cho. ratio than G-B after the 8th wk. of feeding. It was suggested that endurance training would be able to accelerate the catabolism of Chylomicron and VLDL-cho. and so the increase of HDL-cho./T-cho. ratio, which would be favorable for protecting the coronary heart disease.
東海大学の論文

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