5-FUの経口投与による頭頚部悪性腫瘍組織内濃度

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Whether or not 5-fluorouracil (5-FU) administered orally in dry syrup form can reach tissues in cases of head and neck cancer is unknown. 5-FU concentration in the tissues was quantitatively analyzed by bioassay using staph. aureus 209p.The materials analyzed were 121 tissues from 35 patients. However, 4 patients treated with antibiotics at the same time were excluded from this analysis. Although the tissues were obtained at 17 hours on the average after final administration, 24 out of 64 samples (38%) from 17 organs showed existence of 5-FU in samples from the lower lip, palate, tongue, submandibular gland, hypopharynx, larynx, thyroid, neck lymph node and sternocleidomastoid muscle. The average 5-FU concentration was 0.141μg/g wet weight. The uptake in the nose and paranasal sinus region was not detected, while the alimentary canal region from oral cavity to hypopharynx showed a fairly good uptake. The sternocleidmastoid muscle showed 23% (3/13) detection, and the neck lymph nodes 29% (4/14). The tissues affected by cancer showed 41% (14/34) detection, while normal tissues showed 30% (9/30). The 5-FU in the tissues around the cancer showed a higher concentration than that in the center of cancer. The detective rates of 5-FU in the tissues increased slightly according to increase in the total days of administration of 5-FU. A higher dosage of 5-FU calculated by mg per kg bodyweight also showed a tendency toward a high level of 5-FU in the tissues.In summary, 5-FU administered orally was detected in the tissues of head and neck cancer.
耳鼻咽喉科臨床学会の論文

5-FUの経口投与による頭頚部悪性腫瘍組織内濃度

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