蝸牛脂質代謝に関する研究(第2報) : 生化学的および組織化学的研究
スポンサーリンク
概要
- 論文の詳細を見る
The lipid metabolism in the guinea pig cochlea was studied biochemically and histochemically. The results from this study, together with the results obtained by autoradiographic study (ref. 1st report), were discussed. Following conclusions were obtained.1) Autoradiographic study by perilymphatic perfusion of the guinea pig cochlea with 3H-glycerol proved to be fit for the purpose of investigation on the localization of the phospho-lipid metabolism activity in the cochlea. In the autoradiographic study, the most heavily labelled celles were the outer hair cells, especially intensive along the cell membrane, where there were the sheets of endoplastic reticulum (subsurface cisterna). It would appear that subsurface cisterna in the outer hair cells synthesize phospholipids and then supply other biomembranes with these phospholipids.2) Kanamycin depressed the incorporation of 3H-glycerol into the membranous cochlea. Auto-radiographic study demonstrated that this depression was due to the decreased incorporation of 3H-glycerol into the hair cells.3) The turnover of phosphatidyl choline was the most rapid and the rate of decrease in this lipid content by kanamycin was the highest among the all lipid fractions. It seems that inhibition of phosphatidyl choline metabolism as well as that of polyphosphoinositides by aminoglycosidic antibiotics is closely related to the mechanism of cell injury by these drugs.4) Histochemical and autoradiographic studies showed that the lipid globules in Hensens cells contained hydrophilic lipids. These data, together with other data, suggest that the globules may function as an energy source as well as mechanical support of the organ of Corti.It is desirable that the prospective advances of the research on the lipid metabolism in the cochlea will contribute to discovery of a preventive and a treatment for sensori-neural hearing loss. The present study suggests that CDP-choline is useful for a preventive or a treatment.
- 社団法人 日本耳鼻咽喉科学会の論文
著者
関連論文
- 急性小脳失調症の神経耳科学的観察
- 蝸牛脂質代謝に関する研究(第2報) : 生化学的および組織化学的研究
- 蝸牛脂質代謝に関する研究(第1報) : オートラジオグラフィー的研究
- 小脳虫部腫瘍の神経耳科学的観察
- 「良性発作性頭位眩暈症」の臨床的観察 : 眼振出現率の経時的観察を中心に
- Fisher症候群の神経耳科学的観察
- Tracheo-Esophageal Shuntによる喉頭形成の検討
- 小脳脳幹部腫瘍の神経耳科学的観察
- 開頭術を施行した錐体骨真珠腫症2例
- 鼻アレルギ-に対するヒスタグロビンエアゾル療法の基礎と臨床
- 5-FUの経口投与による頭頚部悪性腫瘍組織内濃度
- 慢性副鼻腔炎の治療指針と根治手術の理論と実際
- 耳鼻咽喉科における顔面骨折の臨床-当教室〔京都府立医科大学耳鼻咽喉科学教室〕での過去7年間の集計より
- S状静脈洞血栓症の1例--抗生物質とその陰蔽現象
- 止血剤によると考えられるショックの1例
- Cervical island skin flap 法による口腔底悪性腫瘍摘出後の再建
- 上顎線維粘液腫の2例と粘液腫の分類(水越教授開講10周年記念論文)
- 直接観察法による膜蝸牛血流速度の測定--測定法および血流改善剤(Ifenprodil)の効果判定について
- 蝸牛血流直接観察法による循環改善剤Vinpocetineの効果判定(水越治教授開講10周年記念論文)
- 舌癌に対する新旧,両TNM分類の評価
- 当科〔京都府立医科大学耳鼻咽喉科〕における鼻アレルギ-の統計的観察--血清IgE値と鼻アレルギ-諸検査との相関を中心として
- 顎下部海綿状血管腫の一例 ; 顎下部血管腫の文献的考察
- Case report and survey of patients treated adenocarcinoma of the ethmoid sinus in our university since 1964.
- Bleeding from a giant cerebellar A-V malformation induced by peritonsillar abscess: A case report.
- Three cases of the laryngeal tuberculosis and it's recent trends.
- Three cases of hemangioma with phlebolithiasis of the head and neck.
- 主に前庭症状を示した耳帯状疱疹の1症例-Haymann V型の耳帯状疱疹症例-