蝸牛血流直接観察法による循環改善剤Vinpocetineの効果判定(水越治教授開講10周年記念論文)

概要

論文の詳細を見る
In order to evaluate the effect of Vinpocetine, a new vasoactive agent, on the cochlear blood flow, the numbers of the plasma spaces running through the radiating arterioles per minute at the third turn of the guinea pig cochlea were counted under a stereomicroscope before and after intraperitoneal injection of this drug. The numbers were normalized to the percentages of the number counted before the injection. The percentages at the different times were statistically compared to those of the control by Student's t-test. In each group given Vinpocetine at a dose of 0.5, 1.0 and 2.0mg per kg of body weight respectively, the numbers of the plasma spaces increased significantly at the certain periods from 10 to 30 minutes after the injection. Therefore, Vinpocetine appeared to be useful for treatment of inner ear diseases caused by circulatory impairment.
耳鼻咽喉科臨床学会の論文