口腔粘膜原発悪性黒色腫の5例

概要

論文の詳細を見る
We have reported five cases of malignant melanoma in the oral cavity registered between 1979 and 1989 in our clinic. Sex distribution were four males and one female. The ages ranged from 34 to 79 years and the average was 55 years. Four cases chiefly complained of pigmentation and the other one swelling. Sites of the tumors revealed upper gingiva and hard palate in three cases and only upper gingiva in two. Initial treatments were performed by surgical excision of primary lesion in all cases, combination chemotherapy with DTIC, ACNU and VCR (and, or PEP, BLM) in three cases, radiotherapy in one case, and immunotherapy with OK-432 and BCG (and, or IFN-β, IL-2) in four cases. No recurrences of the primary lesion were seen in any case. Regional lymph node metastases occurred in all cases. These metastastic lymph nodes were treated by radical neck dissection in four cases, irradiation in one case, chemotherapy in three cases, and immunotherapy in four cases. Three cases were alive at that time without local recurrence and distant metastasis. Survival time ranged from 2 years and one month to 7 years and 6 months. One case died of metastasis of the lung one year and three months after the initial treatment and another one died of systemic metastases (brain, lungs, liver, lumbar vertebra) one year and 10 months after initial treatment. Consequently, the cases treated by chemotherapy several times showed good prognosis. Malignant melanoma has been generally poor prognostic neoplasm because of early distant metastasis occurring with early hematogenous and lymphogenous metastases. The therapeutic results in our clinic showed that no local recurrences were seen in any case, and regional lymph node and or distant metastases occurred in all cases. Therefore, it was considered that there was necessity for treating by early and many combination chemotherapies after operation of the primary lesion and or neck dissection in order to prevent distant metastasis of malignant melanoma.
社団法人日本口腔外科学会の論文

口腔粘膜原発悪性黒色腫の5例

スポンサーリンク

概要

著者

関連論文

スポンサーリンク