骨形成因子によるイヌ人工的顎裂部骨架橋形成に関する実験的研究 : 骨架橋形成過程の組織学的検討

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This experimental study was designed investigate the process of bone bridge formation after the implantation of BMP to the maxillary alveolar clefts. Crude BMP obtained from bovine bone matrix was implanted into the artificial alveolar clefts of mongrel dogs, and postoperative bone formation was examined histologically. The results were as follows:(1) Two months after implantation, new bone formation was observed and the area of implantation was filled with undifferentiated mesenchymal type cells.(2) Four months after implantation, bone bridge formation was observed and new bone formation was continued.(3) Most of the bone bridges were suggested to have been formed by intramembranous ossification.(4) The area of new bone formation was limited to areas where BMP had been implanted. These results indicate that BMP is useful for treatment of alveolar clefts.