Effect of ethanol on in vivo hepatic tissue oxygenation and hepatic hemodynamics in rats treated chronically with carbon tetrachloride.

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The acute effect of ethanol administration on in vivo hepatic tissue oxygenation and hepatic hemodynamics was examined in rats treated chronically with CCl4 using organ reflectance spectoro-photometer and thin needle oxygen electrode. In rats treated chronically with CCl4, the hepatic tissue PO2 was lower (5mmHg) than that of normal rats (23mmHg), and the regional hepatic blood volume (ΔEr 569-650), oxygen saturation of hepatic blood hemoglobin (SO2) and in vivo hepatic oxygen consumption (VO2) were respectively 86%, 72%, 82% of normal rats. After administration of ethanol via gastric tube (1g/kg BW.), the hepatic tissue PO2 in normal rats increased, concomitantly with the increase of ΔEr 569-650 and VO2. By contrast, in rats treated chronically with CCl4, the hepatic tissue PO2 did not increase and the increase of hepatic blood volume did not compensate the increase of hepatic oxygen consumption.
財団法人日本消化器病学会の論文