Significance of Australia Antigen and Antibody in the Protraction of acute Hepatitis

概要

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The close relationship between Australia antigen (Au antigen) and viral hepatitis is well established. However, it is not clear how Au antigen does relate to the clinical feature of acute hepatitis. The present study deals with the possible role of Au antigen on the course of acute hepatitis.The results are as follows:1) Protracted case of acute hepatitis is defined as one having the abnormalities in clinical and/or laboratory findings which persist for more than six months after onset.2) No difference was seen in the frequency of protracted cases between Au antigen-related and -unrelated hepatitis. However, in cases without blood transfusion the rate of protraction in Au antigen-related hepatitis was higher than that in Au antigen-unrelated hepatitis, especially in patients younger than thirty years old.3) Frequency of protraction was significantly higher (7/7) in those who showed Au antigen in the serum persistently for more than six months.