CONTINUOUS AND NON-INVASIVE MEASUREMENT OF HEMODY NAMICS AND AEROBIC ENERGY METABOLISM OF GASTRIC MUCOSA BY REFLECTANCE SPECTROPHOTOMETRY:IN RELATION TO THE MECHANISM OF ACUTE GASTRIC MUCOSAL LESION (2)

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The continuous and non-invasive monitoring of the hemodynamics as well as of intracellular energy metabolism of the gastric mucosa of rats has been successful by analyzing the reflectance spectra taken by the organ-reflectance spectrum analyzer which was developed in our laboratory. With reduction in blood pressure to a level of 58mmHg by removing blood from femoral artery, the reflectance spectra of the corpus mucosa of the stomach were characterized by 1) decrement of absorbances in the visible region (400-650nm), especially around 577 and 543nm, which indicated a decrease of oxyhemoglobin supply to this region, and 2) appearance of reduced bands of cytochromes in the mitochondrial respiratory chain, which indicated a severe hypoxia in this mucosal region. In contrast, the spectra of the antral mucosa showed only a slight decrement of the absorbances in the visible region with no appreciable change of the spectral pattern. The mucosal hemorrhage and erosions appeared only in the corpus mucosa. These data indicated that acute mucosal hemorrhage and lesions complicating hemorrhagic shock resulted from the disturbances of aerobic energy metabolism of the gastric mucosa following local circulatory insufficiency.
財団法人日本消化器病学会の論文