Changes in calcium response to hormones in single hepatocytes during culture.

概要

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Many hormones and growth factors exert their actions on liver by generating certain compounds termed second messengers. Recently, it has become clear that Ca2+ can also act as a second messenger, and some hormones exert their actions through Ca2+. The increase in intracellular Ca2+ causes a very large number of cellular changes. To clarify the significance of Ca2+ signalling in hepatocytes, we measured Ca2+ response to hormones in primary cultured hepatocytes. There was remarkable Ca2+ response to vasopressin and phenylephrine early after seeding, but the Ca2+ response weakened, delayed and disappeared during culture. It is known that the numbers of V1-vasopressin and α1-adrenergic receptors on the surface of hepatocytes decrease during culture. This decrease in receptor numbers will reduce Ca2+ response in hepatocytes, and this change in signal transductian will induce the alteration of the generation of physiological response in growth and differentiation.
社団法人日本肝臓学会の論文