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A prospective clinical study was performed to evaluate the preventive effect of cimetidine on acute gastroduodenal lesions and G-I bleeding following head and thermal injury.Acute gastroduodenal lesions developed in twenty three (79.3%) of 29 patients in the control group but only eight (25.8) of 31 patients in cimetidine-treated group (p<0.001). Three of 31 patients who recieved cimetidine prophylactically, had G-I bleeding. On the contrary, fifteen of 29 patients in control group bled (p<0.005).Cimetidine decreased the secretory volume of gastric juice and gastric acidity. A significant reduction of acid output was seen from 1 to 4 hours after intravenous administration. In 6 out 8 patients, cimetidine elevated gastric pH level above 4. In addition, cimetidine prevented reduction in gastric mucosal blood flow.In conclusion, these results indicate that cimetidine has a protective effect against the development of acute gastroduodenal lesions following head and thermal injury.
財団法人日本消化器病学会の論文