臓器反射スペクトル解析による肝病変の機能診断-1-実験的障害肝の血流動態と酸素利用能に関する研究

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The hemoperfusion and oxygen saturation in the liver in situ were analyzed by reflectance spectrophotometry which was equipped with a memory system. The reflectance spectrum of the liver in vivo reflected quantitative and qualitative changes of absorbances of hemoglobin in the blood and of the intracellular absorbing pigments such as respiratory cytochromes. The former served as a signal for the blood supply and average oxygen sufficiency in tissues, while the latter served as an indicator of intracellular oxygen concentration. In livers of rats treated with carbon tetrachloride (2.5ml/kg of body weight) a decreased local hepatic blood volume and a decreased oxygen saturation were observed, reflecting decreases in hepatic oxygen consumption and concentrations in mitochondrial and microsomal cytochromes 24hrs after the tratment.
社団法人日本肝臓学会の論文