飲酒者の肝臓ミトコンドリアならびにミクロゾ-ム酵素の量的変動に関する研究

概要

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The mitochondrial and microsomal cytochromes in human livers were studied in relation to the ethanol metabolism. For this purpose, a micromethod for determining the cytochromes content in small biopsy sample was developed. The results with 62 cases with a variety of liver diseases were as follows; 1) The liver cytochrome a<SUB>3</SUB> content did not significantly change in the drinkers with chronic hepatitis (CH) as compared to that of the non-drinkers, while it slightly decreased in the case of liver cirrhosis (LC), 2) The cytochrome P-450 content significantly increased in the drinkers with CH(P<0.05), while no change was observed in the drinkers with LC, 3) the P-450/b<SUB>5</SUB> ratio of non-drinkers' livers was found to be in linear correlation, while this ratio was variable in the drinkers. The results were discussed in view of the ethanol metabolism in the livers.
社団法人日本肝臓学会の論文