臓器反射スペクトル解析による肝病変の機能診断-2-慢性肝疾患肝臓局所の血流動態と酸素利用能に関する研究

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The hemoperfusion and oxygen saturation in the liver in situ in chronic liver diseases were studied by reflectance spectrophotometry during peritoneoscopy. The results were as follows; 1) The difference in absorption between 569 and 650nm (ΔEr 569-650) and apparent O2 saturation of hemoglobin (Hb) (f) significantly decreased in liver cirrhosis ascompared to those in chronic hepatitis, indicating that the local blood volume and the local O2 content decreased more significantly in cirrhotic livers.2) The ΔEr 569-650 was correlated with serum albumin, prothrombin time and R15 ICG. 3) The ΔEr 569-650 was correlated with the apparent local oxy-Hb content, as measured by f×ΔEr 569-650, suggesting that in the cirrhotic livers the O2 is consumed at a rate as constant as possible, resulting in lowered O2 saturation. Thus the hemoperfusion and O2 saturation in the liver in situ were non-invasively determined in patients' livers. It is concluded that the local hepatic blood volume and/or flow, and the O2 saturation in the liver in situ decreased with development of chronic liver diseases.