Changes in N-Acetyl-β-Glucosominidase Adivity in Chronic Hepotic Domages

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Previous report from our laboratory showed that N-acetyl-β-glucosaminidase (β-GL) activities in serum of patients with various liver diseases were elevated above the normal range and that there was difference in the intracellular distribution pattern of the enzyme between healthy and CC14-damaged liver of rats. In the present study, in order to elucidate the elevation mechanism of the serum β-GL activity in hepatic damage, the interrelation between the serum β-GL activity and the intracellular distribution pattern of the enzyme in the liver was investigated under various conditions. 1) In chronic hepaticdamage induced by CCl4 inhalation, β-GL activities in the serum and the supernatant fraction of the liver were found to be increased simultaneously and the enzyme activities of the particle fractions of the liver, on the contrary, were decreased with advance of the hepatic damage. 2) In the convalescent process from chronic hepatic damage, the β-GL activities were markedly increased both in the particle and in the supernatant fractions of the liver. 3) After administration of excess vitamin A, the enzyme release from the particle fractions into the supernatant fraction of the liver occurred to a more remarkable extent in the damaged liver than in the healthy liver. 4) After administration of hydrocortisone, the β-GL activities in serum, particle and supernatant fractions of the liver reduced slightly both in healthy and in chronic damaged liver, but the decrease was not statistically significant. 5) After 24 hours of bilateral adrenalectomy, the β-GL activity of the paticle fraction of the liver was increased more remarkably in damaged liver than in the control and the enzyme release from the particle fraction of healthy liver was suspected to occur more easily than in the damaged liver.
Japan Society of Clinical Chemistryの論文

Changes in N-Acetyl-β-Glucosominidase Adivity in Chronic Hepotic Domages

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