:A Double Blind And Grossover Clinical Trial

概要

論文の詳細を見る
Two kinds of duuble blind and crossover clinical trials were performed in order to determine the usefulness of glucagon for upper gastrointestinal radiography. 9 healthy volunteers received inactiveplacebo and 1 mg of glucagon intramuscularly preceding the radiographic examination of the upper gastrointestinal tract. Glucagon showed a significantly inhibitory effect on the motility of the gastrointestinal tract. Subsequently, 28 aged subjects ranging from 64 to 90 years (average: 77 years) were alternately given 1 mg of glucagon and 20 mg of butylscopolamine bromide intramuscularly prior to the upper gastrointestinal radiography. When glucagon was given, there was a marked inhibitory effect on the motility of the gastrointestinal tract equivalent to butylscopolamine bromide, yet with fewer side effects. It is concluded that the use of glucagon provides a safer premedication in the examination of the upper gastrorintestinal tract than butylscopolamine bromide in the aged.
財団法人日本消化器病学会の論文