Deoxythiamine関連化合物にかんする研究 : (II)Oxythiamine同族体の合成と微生物におよぼす影響

概要

論文の詳細を見る
Oxydeoxythiamine (oxy-DOB_1), NH_2 group of primidine moiety of DOB_1 was substituted by OH, was synthesized from DOB_1 by applying the method of oxythiamine synthesis from B_1 and its B_1 antagonistic effects on microorganisms were compared with those of DOB_1 Oxy-DOB_1 had no inhibitory effect on the growth and on B_1 uptake of L. fermenti and Kl. apiculata. From these results, it seemed Ithat NH_2 group of pyrimidine moiety was essential to work as B_1 antagonist. To make clear the importance of NH_2 group, other oxy-derivatives of B_1 antagonists, such as chloroethylthiamine and amprolium were synthesized and their effects were tested. Same results as oxy-DOB_1 were observed with oxy-chloroethylthiamine and oxy-amprolium on the growth and on B_1 uptake of the microorganisms.
日本ビタミン学会の論文
1969-01-25