ガスクロマトグラフィーによるβ-受容体遮断剤の分析に関する基礎的研究

概要

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As the basic study of therapeutic drug monitoring (TDM) of β-receptor blocking drugs (β-blockers) by gas chromatography, retention indices were accumulated, and selectivity and sensitivity were compared by flame ionization detector (FID), nitrogen-phosphorus detector (NPD) and electron capture detector (ECD). Retention indices of 15 kinds of β-blockers and those trifluoroacetyl derivative (TFA deriv.) were 2076-3336,1976-2754 (TFA deriv.) on weakly polar column (OV-17), and 1826-2815,1860-2329 (TFA deriv.) on nonpolar column (OV-101). Under the same conditions, retention indices of 19 kinds of concurrent medication were also accumulated as reference materials for TDM. Selectivity was shown by peak area ratio of β-blockers to n-paraffins. Selectivity of NPD was almost 2×10^4 times that of FID. Detectable limits were 10 ng by FID, 0.1-1 ng by NPD and 0.01-0.1 ng (TFA deriv.) by ECD. NPD and ECD showed good selectivity and sensitivity for gas chromatographic analysis of β-blockers.
公益社団法人日本薬学会の論文
1985-12-25