高カロリー輸液用鉄注射剤の院内製剤の調製と輸液中での安定性

概要

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For the purpose of medical treatment or prevention of anemia, the iron injections for intravenous hyperalimentation (IVH) prepared at hospital pharmacy were investigated in Osaka University Hospital. Various stabilizers of iron colloid were comparatively examined and sodium chondroitin sulfate (CSA-Na) was chosen for its high stability in infusion solution. Soluble iron concentration in injections and infusion solutions was determined by atomic absorption spectrophotometry. The CSA-iron injection for IVH contains in each ample 2mg of iron and 10mg of CSA-Na. The preparation methods are as follows : i) add reciprocally iron (FeCl_3・6H_2O) solution and sodium hydroxide solution to CSA-Na solution, ii) adjust pH value to 6.O, iii) filter by 0.45μm membrane filter, iv) sterilize with steam at 121°for 20 min. This iron injection was stable for 72 hours in IVH solution.
日本医療薬学会の論文
1979-05-20