循環器官用薬の溶出におよぼすpHの影響

概要

論文の詳細を見る
The effects of pH on dissolution of forty commercial cardiovascular preparations (antiarrhythmic, diuretic and antihypertensive drugs) were studied in vitro. The dissolution rates were determined by a paddle method in the medium of pH 1.2 and 4.0. Etafenone film coat tablet (Eft), befunolol capsule (Bc), disopyramide capsule (Dc), furosemide tablet (Ft) and pindolol tablet (Pt) showed significant differences in the dissolution rate after 30 minutes at pH 1.2 and 4.0. The differences in the dissolution rate of Eft, Bc, and Dc were due to disintegration process of capsule or film coat. Therefore, those results may be characteristics of those commercial brands. Ft and Pt were more studied using other four and two brands, respectively. In case of furosemide which had poor solubility at lower pH, the dissolution rate of all brands increased as pH (1.2, 4.0 and 5.8) of medium increased. One of three brands af Pt showed dissolution rate of 83% (pH 1.2) and 27% (pH 4.0) after 30 minutes, but the others showed those of about 100% at both pH. The dissolution of those preparations probably depends on pH values in vivo as well as in vitro.
日本医療薬学会の論文
1986-08-20