Nitrazepam製剤の吸光度法による定量法の検討

概要

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The stability of nitrazepam was studied in three different solutions for the assay of the drug. Nitrazepam in the ethanol solution was very stable and showed a linear standard curve at the maximum absorbance of 310 nm. In the first solution (disintegration test, J.P.IX), the ultraviolet (UV) absorption spectrum changed with time. However, no change in absorbance was observed at 252 nm and a linear standard curve was given at this wave length. In the second solution (J.P.IX), the UV absorption spectrum showed no change. For the assay of nitrazepam in commercial tablets, the first solution, instead of ethanol, is preferable as extraction solvent because of its better extraction effect of nitrazepam from tablet ; the wavelength of 252 nm is more precise than the maximum wavelength at about 280 nm for the spectrophotometric assay of the extracted solution.
日本医療薬学会の論文
1976-11-20