点滴時における輸液中アスコルビン酸の安定性に及ぼす通気管有無の影響

概要

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The effects of intravenous drip in fusions with or without aerotube on the stability of ascorbic acid (AsA) were studied by determination of AsA and partial pressure of oxygen. AsA and sodium riboflavin phosphate, which promotes the photo-oxidation of AsA, were added to 14 kinds of commercial in fusion solutions in consideration of practical conditions in hospital. When exposed to white fluorescent lamp (2000 lux, 3 hr), residual ratios of AsA in usual in fusion solutions were 40-60% with aerotube and 11-49% without aerotube. Residual ratios of AsA (2000 lux, 6 hr) in total parenteral nutrition solutions, to which 13 kind of vitamins and trace elements (Fe, Cu, Zn, Mn) had been added, were about 90% with aerotube and about 70% without aerotube. Partial pressure of oxygen dissolved in the solution without aerotube was increased by the bubbling of air during drip administration. Therefore, the oxidizing degradation of AsA in infusion solution without aerotube was promoted when compared with the solution with aerotube.
日本医療薬学会の論文
1985-12-20