食品防腐剤の細菌胞子の発育におよぼす影響

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Effect of some food preservatives and antibiotics upon the germination of spores of Bacillus subtilis Marburg strain has been studied. Results obtained may be summarized as follows: 1. No appreciable difference in the minimal inhibitory concentrations (MIC) of the drugs was observed between those valuse obtained with vegetative cells and those with spores of the test organism (Table 2). Nitrofurazone (NFS), nitrofurylacryl amide (NFA), and chlortetracycline (CTC) were found to inhibit the growth of test organism, while the remaining drugs so far tested did not exhibit the growth inhibition within respective permissible concentration. 2. Concerning effects of drugs on the germination of spores determined turbidimetrically, none of the test drug showed apparent inhibitory action on the germination of spores, on the other hand, inhibition appeared in the growth after germination, so-called outgrowth stage or post-germinative development. Seemingly the rate of inhibition appeared in the outgrowth stage run parallel with the increment of concentration of a drug (Fig. 1 and 2). 3. No marked difference in the inhibitory action of NFS in the outgrowth stage of spores was observed between pH 6.0 and 8.0 (Fig. 3), while sodium dehydroacetate and sodium sorbate were more effective in acidic medium than in neutral or alkaline (Figs. 4 and 5).
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